Sentence examples for chaperone function from inspiring English sources

This domain and the N- and C-terminal extensions are considered the main functional units in its chaperone function.

We then asked if the PTEN DAXX complex modulated the histone H3.3 chaperone function of DAXX.

Moreover, we found that NAC also exerts a ribosome-independent chaperone function invivo.

The chaperone function of ClpB from Thermus thermophilus depends on allosteric interactions of its two ATP-binding sites.

Importantly, our data indicate that DnaK positively regulates the amount of RpoS (Fig. 3a) through its canonical Hsp70 chaperone function (Fig. 3b).

Here, we investigate the cell-wide consequences of loss of chaperone function in cytosol, mitochondria or the endoplasmic reticulum (ER) in budding yeast.

The ideal therapeutic compound should either prevent GRP78 surface translocation or suppress the GRP78 receptor signaling, while preserving the GRP78 chaperone function in the ER.

To our knowledge, this is the first successful attempt to rationally design an assembly chaperone with improved chaperone function.

HDAC inhibitor-mediated deregulation of chaperone function, in turn, deregulates protein homeostasis and induces protein misfolding and proteotoxic stress.

KBU2046's precision type of effect on chaperone function differentiates it from classical HSP90 inhibitors, which broadly disrupt client protein function, and underlie KBU2046's lack of toxicity and selective modulation of cell motility.

The double-ring assembly of GroEL is required for the chaperone function, and a single-ring variant GroELSR is inactive with GroES.