Sentence examples for chaperone effect from inspiring English sources

Two separate criteria were set for evaluation of the chaperone effect: a relative increase of enzyme activity (more than 3-fold), and an increase up to more than 10% normal enzyme activity.

This mechanism, often referred to as a "chemical chaperone" effect, may be sufficient to drive proteins to fold, bind, or shift towards aggregation [19] [22].

Although, a possible explanation for a lack of chaperone effect on α-synuclein metabolism could be due to a non-functional or only partially functional HSP70 as in vivo functionality of the overexpressed human HSP70 in mice has not been determined due to several experimental challenges.

In addition, the chaperone effect of glycosphingolipids is not irreversible.

How could this concept of a sphingolipid-mediated chaperone effect apply to membrane-bound amyloids?

This chaperone effect of sphingolipids is a direct consequence of the unique modalities of protein sphingolipid interactions (Ref. 49).

In order to assess the generality of molecular chaperone effects upon APP proteolytic processing, comparative titrations were performed with the NAG cells using three different small molecular chaperones: PBA, TUDCA, and DMSO.

Neuropeptides are an attractive system in which to utilize chaperone effects in order to remedy protein misfolding in a variety of disorders (for reviews, see Arakawa et al., 2006; Fan and Ishii 2007; Parenti 2009).

One possible mechanism of increased sensitivity to acetylcholine is a pharmacological chaperone type effect by neonicotinoids, leading to an up-regulation in nAChR expression.

In this regard, and because in the interior of cells the formation of the many native proteins depends on the existence of chaperones, it could be considered that the proteins we studied favor dimer formation through a chaperone-like effect.

In some cases, the chaperone-like effect of 14-3-3ζm 14-3-3ζm 14-3-3ζmr even higher, than that of the small heat shock proteins, HspB6 and HspB5.