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Our results map the distribution of the HIRA chaperone across the chromatin landscape and point to different interacting partners at functionally distinct regulatory sites.
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One potential mechanism to explain cell and tissue vulnerability could be related to diversity in the expression of protein chaperones across different neuronal populations and different tissues.
It is possible that there is even less variability in the levels of chaperones across brain structures than is predicted by the ABA.
1 Recent studies have indicated insufficient use of chaperones across primary as well as secondary care.
We found that a common feature of most of the histone chaperones across the diverse seven families is the presence of one or more low complexity regions (LCRs), which are stretches of polypeptide sequence highly rich in one or a few amino acids.
For example, Stephens suggests an app that would let college students request one to chaperone them across campus at night.
TP2 and the LRLLR motif peptide induce lipid translocation, suggesting that lipids chaperone them across the bilayer.
This normalized abundance allows comparing relative chaperone levels across experiments.
A multivalent chaperone network within and across the editing modules establishes the proofreading function at two lateral binding platforms for MHC-I molecules.
The Tim8 Tim13 complex assembles as a hexamer and binds to the substrate Tim23 to chaperone the hydrophobic Tim23 across the aqueous intermembrane space.
ApoE is an Aβ chaperone, promoting its transport across the blood brain barrier (BBB), a process that is known to be impaired in AD [ 18- 20].
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