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Human K2P2.1 (TREK1) and hK2P3.1 (TASK1) channels were systematically tested for their sensitivity to clinically relevant class IA (ajmaline), class IB (mexiletine), and class IC (propafenone) antiarrhythmic compounds using whole-cell patch clamp and two-electrode voltage clamp electrophysiology in Chinese hamster ovary cells and in Xenopus oocytes.
The following selection criteria were applied: all spots having a mean signal (after background subtraction) less than that of the background and below that of the negative controls in both Cy3 and Cy5 channels were systematically excluded; the data were also filtered to exclude spots flagged as missing or corrupted in one array.
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Disease-related mutations of various Nav channels are systematically mapped onto this Nav1.7 structural model.
The optimal value of the number of reserved channels is systematically searched by using the fact that new call blocking (handoff failure) probability is a monotonically increasing (decreasing) function of the number of reserved channels.
The heat transfer and fluid flow characteristics of the vortex-generator channel were systematically analyzed by 3D-CFD simulations.
The cross-section of the supraglottal channel was systematically varied by increasing the distance between the lateral channel walls.
Confocal aperture was set to the minimum during line scans, and matching with the mRFP fluorescence in the red channel was systematically checked.
The influences of crystallographic orientations on the evolution of dislocation structures and the refinement process of sub-grains in Al single crystals processed by one-pass equal-channel angular pressing (ECAP) were systematically investigated by means of scanning electron microscopy, electron backscatter diffraction and transmission electron microscopy.
Responding to this concern, test batteries were developed where mice were systematically channeled through extensive tests of general health, reflexes, motor function and cognitive abilities (reviewed in [ 12]).
The pore-channel aspect ratio and the crystallographic orientation of the channel axis within the m{10¯10} plane were systematically varied over wide limits.
Millions were systematically killed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com