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These AIS Kv1 channels may function in MNs, as in layer 5 pyramidal neurons, to regulate the duration of action potentials [ 12] or, as in neocortical fast-spiking γ-aminobutyric (GABA)ergic interneurons, to control the action potential threshold and thus the firing rate [ 14].
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It is still an open question whether S-type anion channels and microtubules may function independently, or whether they act together to regulate stomatal movement.
T. thynnus – trans-membrane channel protein 6 (Tmay) may function to transiently accumulate inorganic ions, specifically Cl- ions into the oocyte thus raising the osmolality required for full oocyte hydration.
Alternatively, TRPV4 channels may not function directly as the mechanosensor, rather as critical components of down-stream signaling (reviewed in Liedtke and Kim 2005).
These studies strongly suggest that a conserved cascade of intracellular events leading to β-cell insulin secretion, namely closure of KATP channels and opening of voltage-gated calcium channels, may also function in adult fly IPCs.
The possibility exists that the rate of HCO3− influx during Cl− removal could be underestimated because other electrogenic chloride channels may also function to pump out Cl− ions to lessen the concentration gradient of the ion across the plasma membrane.
In addition to function as a water channel, AtPIP1 2 and NtAQP1 may function to facilitate CO2 transport and enhance photosynthesis by increasing the mesophyll conductance to CO2 diffusion [ 55- 59].
While the discovery of this gene family is relatively novel, a consensus is building in the literature that these proteins may function as ion channels, pumps or transporters [ 48- 50].
Kv4.2 channels in the extrasynaptic plasma membrane may function to counteract excitatory postsynaptic depolarizations and limit back-propagation of action potentials into distal dendrites, thereby reducing the excitability of the neuron and gating neuronal firing (Goldberg et al. 2003; Migliore et al. 1999).
The structure of synaptophysin suggests that the protein may function as a channel in the synaptic vesicle membrane, with the carboxyl terminus serving as a binding site for cellular factors.
Two transcripts that matched an A. thaliana expressed protein and Pisum sativum core protein may function as membrane channel proteins.
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