Sentence examples for channel conformation from inspiring English sources

However, our view recently changed when a second crystal structure was reported, in which a P2X receptor was bound to ATP and resolved in an open channel conformation.

It is assumed that the hydroxymethyl moiety of 4a stabilizes the closed channel conformation by an H-bond with Glu236 as does the phenolic OH moiety of 3, Ro 25-6981 and ifenprodil.

We believe that the two components of the E519C fluorescence signal are related to two separate reorganizations of channel conformation.

Implementation of the proposed anti-Hebbian rule would require detecting not only neuronal activity, but the coincidence between neuronal activity and channel conformation or conductance.

The crystal structure of the open channel conformation is consistent with these electrical measurements if the cationic sidechains 2 5 move from inside to outside and that at site 6 moves from a midway point to outside upon channel opening ('outside' and 'inside' refer to extra- and intracellular compartments).

Our data suggest that use-dependent block of CaV1.2 by diltiazem occurs predominantly via the open channel conformation.

In addition, only the mrm and rmr PS stereoisomers show channel conformations with significant probabilities, so we suggest that in situ polymerization of styrene monomer in the narrow channels of its IC formed with γ-CD might produce a new stereoregular form of PS with regularly alternating m and r diads.

Heterogeneous channel conformations as observed in the average Aβ barrels structure are similar to the structure of Aβ channels with various sequences in our previous simulations.

Comparisons of the structures of KcsA and another simple bacterial potassium channel, MthK from Methanobacterium thermautotrophicum, 9) have suggested they represent closed and open channel conformations, respectively.

Then ∼8-ns unrestrained GB-MD simulations were performed on the final channel conformations except residues located at the S5 and S6 segments restrained by a force constant of 0.02 (kcal/mol)/Å, and the membrane environment was simplified in our work.

This specific orientation could not be kept in the closed-channel conformation since the bottom (more intracellular) portion of KCNE1 severely clashed with the S1 segment of the adjacent subunit.