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However, hERG channel blockade is an important indicator of potential pro-arrhythmic liability.
Detection of drug risk by channel blockade is considered essential for drug regulators.
The molecular determinants of hERG channel blockade have been defined using a site-directed mutagenesis approach.
Findings suggest a potential role for sodium channel blockade in relieving pain of OA.
This drug is unique because it has multiple mechanisms of action, including blood vessel dilation and a calcium channel blockade.
The first structure of a sea anemone potassium channel toxin reveals how a novel structural scaffold can be used to present key functional groups for channel blockade.
Sonna, L. A., Hirshman, C. A. & Croxton, T. L. Role of calcium channel blockade in relaxation of tracheal smooth muscle by extracellular Mg2+.
Proarrhythmic response to potassium channel blockade.
Theoretical characterization of ion channel blockade.
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Effect of M-channel blockade on the distribution of short interspike intervals.
Pharmacological K-channel blockade restores blood pressure and improves mortality in animal models of sepsis.
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