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Although the RBS concept also shows promise for evaluating sediment and bed stability in individual streams, our approach is relatively coarse, so site-specific assessments using these rapid field methods might prudently be confined to identifying severe cases of sedimentation or channel alteration.
Simulating the full axonal excitability recordings with this model is depicted in Fig. 5. Overall interpretation incorporating mathematical modelling suggested a combination of changes in passive cable properties and axonal ion channel function, with a reduction in fast K+ channels as the most important channel alteration.
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We analyze the long-term effects of channel alterations that may affect flood hazard.
Cocaine might induce AIVR either through the production of myocardial ischemia or as a direct result of ion channel alterations [3, 9].
This idea is further supported if the consequences of Dp71 deficiency are studied one step downstream of the channel alterations, by assessing the swelling properties of Müller cells.
Our present results confirm that functional expression of Dp71 is necessary for the highly asymmetric expression of the inwardly rectifying potassium channel Kir4.1 in Müller cells, and suggest that Dp71 downregulation is one step upstream of the Kir4.1 and AQP4 channel alterations in the signaling cascade of reactive gliosis.
Moreover, if BPA induces ion channel alterations in atrial tissue, exposure will likely affect ion channels in other tissue compartments.
Potassium current change can result from blockade of the potassium channel, alterations of ion selectivity, or reduction of hERG protein expression.
In addition, landscape development in the region is mainly controlled by climate and neotectonics, without major fluvial channel alterations in the recent past (i.e., late Quaternary).
The QT prolongation seen in our study is most probably the consequence of potassium ion channel alterations induced by arsenic, and may involve hERG trafficking defects.
We found that the characteristic time τ C a 2 + of Ca2+ channel alterations in response to step changes in Ca2+ is inversely proportional to the total number of channels.
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