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"We would recommend changing the ventilator settings, for example, but it wouldn't be how they practiced.
The pre-oxygenated and warmed perfluorocarbon liquid (30 ml/kg) was instilled into the trachea over 15 min without changing the ventilator settings.
The oxygenated and warmed PFC liquid (30 ml/kg) was instilled into the trachea over 5 min without changing the ventilator settings.
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Second, our study design, with sequential changes in the ventilator settings, was susceptible to carryover phenomena.
At simulation of each change to the ventilator settings, the following constraints were applied.
Before any change of the ventilator settings a recruitment maneuver was performed.
Ventilatory adequacy was monitored by arterial blood gas measurements, with the ventilator settings changed as needed.
During this application, the position of the patient (supine) and the ventilator settings were not changed.
The amount of ventilation to the regions studied was reported according to the ventilator settings used.
Although the continuously operating vibrating mesh nebulizer was optimally placed in the ventilator circuit, the ventilator settings were not controlled.
The dosage of inotropes and vasopressors was kept constant during dialysis, as were the ventilator settings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com