Sentence examples for changing the specificity from inspiring English sources

The effector specificity could be rationally changed by changing the specificity of the conjoined aptamer: when a mutation was introduced into the anti-theophylline aptamer that led to discrimination against theophylline and in favor of 3-methylxanthine (that also differed from theophylline by a single methyl group), the aptamer became solely responsive to 3-methylxanthine in vivo.

It provides a new direction for future research into changing the specificity of REases.

During this recombination process one of several sets of downstream CH exons replaces the Cµ exons and the intervening sequence is deleted from the chromosome, which results in expression of a new C region without changing the specificity of the IgH variable region [5].

Changing the specificity of a kinase, therefore, can destroy many network connections, while also potentially creating a large number of new connections.

In both cases, changing the specificity of the regulator gene either a kinase or a transcription factor can potentially lead to the loss of essential network connections and also potentially create a large number of new connections.

Indeed, such a plasma membrane localisation caused by substrate binding has been suggested by the work of Kunz et al. [19,20], who, by changing the specificity of a Type I PIPkin (which uses PtdIns4 P as a substrate) to that of Type II PIPkin (which uses PtdIns5P), and vice versa, showed that changing substrate specificity of PIPkins can alter their localisation.

In this regard in the present work we have produced a variant of chimeric protein, named PD-L4UWSCItr, changing the inhibitory specificity of WSCI domain.

However, just changing the receptor specificity of HPAI H5N1 virus was insufficient to confer airborne transmission between ferrets.

The revision incorporates new knowledge and technology to improve especially the sensitivity of the Task Force criteria without changing the high specificity.

In light of that, researchers have been developing different approaches to artificially increase the chemical diversity of NRPs by changing the substrate specificity of A domains.

Interestingly, changing the Dbf4 specificity of HsCdc7 to Sc Dbf4 relieves the HU sensitivity, suggesting that resistance to HU is provided by Dbf4.