Second, in some cases such as cancer, mutation of miRNA sequences may cause activity changes without substantially changing the expression levels.
Further, the later stage of infestation by whiteflies also leads to changes in amino acid metabolism by changing the expression of threonin aldolase and 4-hydroxyphenylpyruvate dioxygenase (Table 3).
Emerging data suggest that stress conditions can alter the biogenesis of miRNAs, thereby changing the expression of mRNA targets.
However, changing the expression of key genes and transcription factors may also cause many problems, such as tumorigenesis and insertional mutagenesis11.
Changing the expression of key genes and transcription factors, such as osteopontin (OPN), TGF beta and PP2Acα8,9,10, can also increase hepatocyte proliferation and liver regeneration.
The induction of ABC transporter genes during silicification also revealed that cells respond to mineralization by changing the expression of their genome and adapting membrane exchanges34.
We have successfully analyzed the gene expression profiles of needle biopsy tissues using the modified method without significantly changing the expression profiles.
Nightloads of tequila and cigarettes, dawn shoots, three marriages and countless affairs, including one with Marlene Dietrich, aged the face without changing the expression.
As shown by various studies, the HDR-NHEJ ratio can be regulated by either changing the expression of machinery mediating DNA repair or optimising delivery methods and timing.
Nano-TiO2 causes liver and brain toxicity mainly through increasing oxidative stress, decreasing antioxidant levels, and changing the expression of the protective genes in the liver.
These clues point to a possible evolutionary mechanism: natural selection operated to increase taste receptors and jaw size through changing the expression of shh (and likely other genes).
