Sentence examples for changing the affinity from inspiring English sources

By changing the affinity probe pairs this method could be easily expanded for other protein analytes, showing promising potential for point-of-care testing and extensive applications in bioanalysis.

Histamine (i) stimulated phosphoinositide hydrolysis (EC50 = 8.6 +/- 4.1 microM), (ii) activated protein kinase C (2.4-fold increase in activity), and (iii) increased phosphate uptake (EC50 = 3.2 +/- 1.8 microM) by increasing maximal transport (Vmax(basal) = 6.2 +/- 0.3 versus Vmax histamine) = 9.1 +/- 0.4) without changing the affinity of the transport process for phosphate.

Finally, we investigated how phosphorylation of S776 modulates interaction and found that, while not significantly changing the affinity for the two UHM proteins, it determines a quantitative shift towards complex formation with 14-3-3 14-3-3 14-3-3

Bellini et al (2010) reported that these polymorphisms are associated with differences in promoter activity by changing the affinity for distinct transcription factors.

To date, it has been observed that the FCRL3 −169T>C SNP affects the expression of FCRL3 by changing the affinity binding of nuclear factor-kappa B (NF-κB) to its promoter.

It has also been demonstrated that changing the affinity of a coiled-coil interaction in a MAPK signaling assay can tune the effect of a modulator and create complex pathway responses.

Therefore, an increase in IL-6-producing Ag-presenting DC could lower the affinity threshold for Tfh-cell differentiation without changing the overall affinity threshold for clonal selection of the whole Ag-specific CD4+ T-cell repertoire.

The release kinetics of growth factors can be molecularly modulated by either changing the binding affinity of the aptamer or by using a triggering effector.

Therefore, we proposed that by changing the binding affinity of the fibroblast to collagen, integrins are causing the induction of intracellular ROS, which leads to oxidant stress and caspase-3 activation.

While the importance of the PPLPLL motif in IL-3 has long been demonstrated by neutralizing antibodies and by mutagenesis [26], [35], the observation that a number of mutations in this region can increase the specific activity of IL-3 without changing the binding affinity of the receptor has been puzzling [35].

Nevertheless, it has been postulated that early release is important for the functionality of the reprotonation switch, as it ensures irreversibility of the M1 → M2 reaction by changing the proton affinity of Asp85.