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Changing the active compound or the in-house reference library will likely change the results.
Mutation of Ser-182 and/or Ser-186 to alanine alters the hydrogen bonding network, changing the active site architecture.
All but four of the 33 mutations occur in locations remote from the active site and act by fine-tuning rather than directly changing the active site configuration.
In the end, Denis was actually the active one.
And that's just the active ones.
The most attractive ones are usually considered the active ones.
Active almost three decades, Bill, Kathy -- and their incredible cadre of global volunteers -- are changing the world -- one smile at a time.
"Everyone thinks of changing the world, but no-one is thinking of changing himself".
Changing either can affect the project, even if you're changing the needles for different ones of the same size.
The film-coating of tablets was necessary to avoid a photo-induced color changing of the active pharmaceutical ingredient.
The light causes the nanoswitch to deform, in turn changing the peptide into an active shape.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com