Demaria, S., Coleman, C. N. & Formenti, S. C. Radiotherapy: changing the game in immunotherapy.
Changing chemotherapy and radiotherapy management schema and the small size of this cohort precluded investigations by current practice categorizations: type of chemotherapy (platinum vs. non-platinum), use of radiotherapy, radiotherapy dose/schedule, lactic dehydrogenase (LDH) or other lab results.
With radiotherapy techniques dramatically changing the dose and volume of radiation for so many sites of radiotherapy, the applicability of the outcomes from the large epidemiologic studies of earlier decades utilizing outdated techniques to the modern context is unclear.
The paper reveals the changing pattern of Bulgarian Radiotherapy (RT) care after the successful implementation of 15 projects for 100 million euro under the European Regional Development Fund in Operational Programme for Regional Development 2007 2013.
However, the baseline standard management of brain metastasis is also changing, and focal or stereotactic radiotherapy instead of whole brain radiotherapy has been increasingly utilized.
Exclusion criteria were age less than 18 years and older than 85 years, rectal cancer, and abdominopelvic radiotherapy, severe complication, changing regimen, multi-primary cancer, family history (first-degree and second-degree relatives had any kind of cancer), familial adenomatous polyposis.
For example, changing the window setting changes the interpretation of lesion margins; the optimal window setting for radiotherapy contouring applications has yet to be determined.
What action threshold criteria should be adopted in adaptive radiotherapy to conform to changing morphology, molecular phenotype, and respiratory-induced tumor motion patterns?
F-MISO PET is able to monitor the changing hypoxia status of tumours during radiotherapy.
[F]MISO PET is able to monitor the changing hypoxia status of lung tumours during radiotherapy [ 16].
