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In the list of 144 significantly changing proteins in AD platelet membrane fractions, we found five additional proteins that have been identified as potential biomarkers or have a function homologous to such a protein (Table 3).
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Significance was assessed using ANOVA resulting in 210 significantly changing proteins, and 193 of these proteins were associated with a gene symbol and could be used for enrichment calculations with the pathogen interactor lists.
In these cases, non-3n indels may not have significant effects in changing protein abundance, and thus may be tolerated by selection.
Changing protein concentrations allows producing adsorption isotherms that, in turn, are used to calculate protein binding affinity.
Protein manipulation was achieved by varying commercially available foods in the diets and by changing protein contents within foods (eg, low-protein bread).
Protein phosphorylation is very common in eukaryotes and is known to influence protein function by changing protein-protein binding properties, structural stability and spatial organization [ 50].
Within each fold, first a test of differential abundance between the CRC group and the controls was employed to narrow down the candidate list to a subset of significant proteins changing in abundance in CRC (P-value ≤ 0.05, FC cutoff ± 1.1) (Appendix Table S2A).
Through this analysis pathways associated with the transition from pre-malignancy to malignancy would be significantly represented in the dataset of proteins changing in abundance, but not in the dataset of control proteins.
Arrow indicates proteins significantly changing in abundance in comparison with control (ANOVA, p < 0.05).
As a whole, the proteins identified as changing in abundance in response to OP exposure respond quite similarly to their transcripts.
5) Supersaturation scores indicated an increased propensity to aggregate in proteins changing in abundance after heat stress at 24 hours and 48 hours.
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