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In summary, our study indicates that anti-glycan antibody levels are changing in patients with CD whereas the status of the markers is stable over time.
Such age relationship was further reported when monitoring atypical nevi, with about 10% of them changing in patients younger than 28 years of age but in only 3% of adults older than 48 years [ 55].
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In the Gencosmanoglu study, the PEG tube was able to be removed in 14% of patients and required changing in 10% patients; these rates are nearly identical to our study in which 13% patients were able to have the PEG tube removed and 12% required the PEG tube to be changed.
The injured spinal cord is still changing in many patients during the first year (Marino et al., 1999), and transplantation during this period may be more effective.
Cluster RCTs are becoming increasingly common in health services research, being particularly appropriate for evaluating interventions aimed at changing behaviour in patients or practitioners or changing organisation of services.
CILDI appears to be accurate and precise in measuring changing GFR in patients with AKI.
However, because of changing demographics in patients who require total knee arthroplasty, i.e., shifting to a younger population with higher functional demands, newer designs have been developed to achieve greater survivorship and clinical outcomes.
Therefore changing behaviour in patients might be more difficult.
A more plausible explanation could be the changing trends in patients' characteristics, improvement of surgical techniques and intensive care management over the years.
Until these datasets can be fully explained, the role of the phosphate binders – and specifically different types of phosphate binders – in changing outcomes, in patients with CKD who have not yet progressed to ESRD and in patients with ESRD, will remain a focus of future research.
The present study suggests that, in Brazil, similar to what has been reported from developed countries, mortality patterns among HIV/AIDS patients are changing in the HAART era.
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