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It also seemed unlikely that the declines in dATP abundance were caused by changing cell cycle distributions in the ∼4000 8000 cell embryo at the MBT, since S-phase is when dNTP levels would be expected to be highest if these levels were cell cycle regulated at later stages of development [23],, but the first cell cycle phase to be extended at the X.laevis MBT is the S-phase [27].
Changing cell cycle regulator activity can alter the length of time that cells spend in growth phases G1 and G2 before dividing, thus affecting cell size.
As icariin was renal protective by changing cell cycle distribution of renal cells [ 21] and was shown to promote the maintenance, activation, and differentiation of many types of stem cells [ 13– 18], we postulated that the action of icariin in improving renal function would involve the activation of pathways promoting the proliferation and/or homing of renal stem/progenitor cells (Fig. 7).
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MCM2 and CKS2 were chosen as examples of early/transiently changing cell cycle-associated genes (sets 1 and 2).
This suggests that changing of "Cell cycle" pathway is likely to affect other pathways.
Therefore, we concluded that irradiation did not potentiate ONYX-015 by changing the cell cycle profile.
Two types of changing cells were identified.
Prostate cancer cells (PC3) were treated with 2DG for 6 h or 48 h to analyze the changing of cell cycle and autophagic flux.
Centrosomal proteins often exhibit cell cycle-dependent localization to the organelle, with their levels changing during the cell cycle.
Changing trends in cell cycle regulators seen in MCF10A cells were also seen in the tumorigenic hMEC cell line MCF7.
When complete, the recipe will be packed to generate the first 3D structural model of a whole cell and the first structural snapshots of a whole cell dynamically changing over an entire cell cycle.
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