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Given that 18 of the 61 non-stop genetic codons can be changed into stop codons by changing a single base, the total length of the two exons in each IGHV gene segment is ~355 bp, and a human generation is 25 years, about 21.7 million years is needed to change an IGHV gene segment in an ORF into a pseudogene segment.
Scientists' favourite method, Crispr/Cas9, makes precise changes to individual genes, even changing a single "letter" of the genetic code.
In this case, changing a single line of code can change the aggregation's running time from linear to logarithmic in the number of values being aggregated.
For instance, changing a single digit in one cell of an Excel spreadsheet changes the sums or products in other cells.
The first component, the sensitivity (S, eqn 2a) we re-defined as 'the average proportional change in λ of the hybrid population, caused by changing a single transition in any plant type'.
They are clothes that can be shrunk down and worn by 7-year-old girls without changing a single design element — if there were actual design elements to change.
Sensitivity measures and metamodels show the combined effects of changing a single input and how to remedy unwanted output changes.
I'm not changing a single note.
Without changing a single thing about his platform, Cain will magically become viable.
Changing a single word or altering the pace or emphasis can make a previously failed witticism work.
Most software is fragile: even the slightest error, such as changing a single bit, can make it crash.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com