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Endpoints were tumor response and radiation induced changes within the lung tissue.
LAM is characterized pathologically by widespread proliferation of abnormal smooth muscle cells and by cystic changes within the lung parenchyma.
This case report describes a horse with clinical signs and histological changes within the lung that correspond with the recently described disease EMPF [ 11] that has been associated with infection by EHV-5.
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MDCT is more sensitive than plain radiographs in detection of structural changes within the lungs.
MDCT is more sensitive than plain radiographs in the detection of structural changes within the lungs, e.g. large and small airways disease and lung parenchymal consolidation [6].
However, mainly due to the volume and pressure changes within the lungs during the respiration, it is reasonable to expect that the local perfusion be different according to the respiratory phase.
Similarly, the American Thoracic Society and the European Respiratory Society acknowledge that the systemic manifestations of COPD are likely to be, at least in part, the result of shared mechanisms that also contribute to the structural and functional changes within the lungs, including systemic inflammation, altered apoptosis, and oxidative stress (74).
Much less is known about regional volume changes that occur within the lung during recumbent rotations along the unchanging horizontal axis, especially in the setting of non-symmetrical chest disease.
For this reason, a different approach was necessary, based on the rationale that the distribution of ventilation will change within the edematous lung and that, owing to gravity, fluid will accumulate in the dependent parts.
The relative percentage changes within the regions of the lung were also assessed to more clearly demonstrate the shift in vibration energy and were also presented.
Paraffin-embedded tissue sections (5 μm) were stained with haematoxylin and eosin Y (H&E) for general histology and the assessment of pathological changes and Masson's trichrome staining was used to identify changes to collagen content within the lung parenchyma as previously described [ 18].
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