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Dose changes will be recorded.
All treatment changes will be recorded.
Ideally, these types of changes will be recorded directly in the repository in the future.
All changes in conventional treatment, with the reasons for these changes, will be recorded throughout the study period.
Clinical care will continue as usual for both groups throughout; any medication changes will be recorded for potential subset analysis.
Medication changes will be recorded, with all efforts made to avoid change of anti-hypertensive medications during the six week trial.
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The total number of visits with recommended medication or lifestyle modifications and the time to the first treatment change will be recorded for all subjects.
Changes to these will be recorded at follow-up visits.
All consultations between scheduled study visits, as well as changes in treatment, will be recorded.
If the time is changed because of an increase in having to euthanize mice due to complications, the change in timeframe will be recorded.
Patient-perceived satisfactory improvement (PPSI): Participants' perceived global rating of overall change (from baseline) will be recorded on a 5-point Likert-type scale (1 = much worse, 2 = slightly worse, 3 = no change, 4 = slightly better, 5 = much better) [ 36].
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