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Overall, pathologic changes were mild.
Reminiscent of human disease (and the macaque model) viral burden in the liver was high, but histological changes were mild.
Vital sign changes were mild and not clinically significant; however, a mean 1.04 kg weight loss was observed for the group (p < 0.001).
In control cells, [Ca2+]c changes were mild and similar in the presence or absence of Aβ (0.67 and 0.3 μ m, respectively) (Fig. 3C).
The general condition and demeanour were abnormal in 429 (93.1%) cattle: changes were mild in 194, moderate in 202 and severe in 33 patients.
In the context of recent concerns regarding the safety of adenovirus vectors, it is important to note that these changes were mild (maximal four-fold increase of serum ALT) In one patient, intratumoural virus replication was documented although no objective tumour responses were observed.
Similar(53)
Heart scans did show impaired blood flow to the heart muscles of most patients, but the sauna-induced changes were milder than the exercise-induced abnormalities.
The changes were milder in the group 3 cats.
Histological changes were milder at day 8 than at day 25.
In groups immunized with unadjuvanted or poly(I C -adjuvanted FSm14/29, fewer and smaller cellular granulomata were seen and parenchymal changes were mI C -adjuvantedrols.
Another advantage in such cases is the possibility of sampling at early stages of disease, when pathological changes are mild to non-existent, while continuing the follow up for subsequent disease progression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com