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Enard et al. [ 42] reported that when human-specific coding changes were engineered in mice (partially 'humanizing' them at the locus), this resulted in an altered structure of innate pup vocalizations, decreased levels of exploration, decreased levels of dopamine in the brain and an increased dendrite length and synaptic plasticity in the striatum.
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But the paper's tone was one of resignation in the face of the inevitable: "That's the way such things work in New York: Social change is engineered by taxing and regulating a product well beyond the bounds seen elsewhere".
Change was engineered," said Erualdo Gonzalez, an associate professor of Chicano studies at Cal State Fullerton who studies gentrification in Santa Ana.
In synthetic lethality screens, the forward approach uses the genetic variability in a collection of cancer cell lines whereas in the reverse tactic a single specific genetic change is engineered resulting in an isogenic cell line pair.
Compact yet also capacious, with roots in myth, they were engineered to accommodate changes in cultural values and conflicts.
Mutations were engineered by Quick-change mutagenesis (Agilent Technologies) in a pcDNA3.1-Kv7.2 pcDNA3.1-Kv7.2lectroplasmidogical and western-blot experiments), or in a dual-tagged Enhanced Green fororelectrophysiological-hemandlutinin (EGFP-Kv7.2-HA) plasmid (for immunocytochemistry experiments), as described21,34,61.
A dialogue is fine, but the change should be engineered through the structure that exists on campus".
A critical step in cellular transdifferentiation is morphological change, which is engineered by the reorganization of cytoskeletal elements such as microtubules.
Weapons of mass destruction (WMD) barely got a mention and even assertions that sincere efforts were made to avert war were based on the possibility that regime change could be engineered by other means.
To test this hypothesis, CS-HA1ΔGly, a mutant in which the unique N-glycosylation site Asn316 was changed to Ile, was engineered by site-directed mutagenesis.
In 1953, after Iran's populist Prime Minister Mohammad Mossadeq challenged Britain's imperial monopoly over his country's oil industry, Eisenhower authorized a covert regime change operation to be engineered by the CIA and British intelligence.
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