Sentence examples for changes were designated from inspiring English sources

Of these, 136 brains with pathologically minimal senile changes were designated as control elderly brains (78.5 ± 9.7 y).

Strains with no aa changes in the ISDR, with 1 to 3 aa changes, and with > 3 aa changes were designated as wild type, intermediate type, and mutant type, respectively.

In cases where |S| = |R|, i.e., the genes show increased and decreased expression in equal number of animals, such expression change was designated non-interpretable and step 2 was not necessary.

An over-expression fold change is designated with a positive number.

Probes with no copy change are designated as 0, probes with one copy loss designated as -1, probes with a copy number gain designated as 1, and probes with amplification designated as 2. Uncentered correlation using the means of all pair-wise data points for distance metrics (average linkage) was used for cluster analysis [ 31].

Finally, to select for statistically significant changes, genes were designated as 'differentially expressed' if the corresponding ratios varied by at least 2-fold in at least 2 out of 56 samples (consistent with recommended criteria [67], [68]).

These changes at identical positions were designated "homologous modification sites".

miRNAs with log2-fold changes higher than 1 were designated as significantly up-regulated, and those with log2-fold changes less than -1 were designated as significantly down-regulated.

Similarly, miRNAs with the log2 fold changes less than −1 were designated as 'down-regulated'.

In the two libraries, miRNAs with log2 fold changes higher than 1 were designated as 'up-regulated'.

Subsequent histopathological analysis evaluated tissues from this group showing the most intense changes in trigeminal sensitivity and were designated as the selected RCHI group.