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The interevent time for formation changes was defined by (tau^{k}_{i} = t^{k}_{i}-t^{k}_{i-1}) ((1le ile N_{k})).
Anatomical localization of the cerebral areas showing GM changes was defined by an experienced observer, using the Talairach Daemon.
The extent of genomic changes was defined as the fraction of the genome altered (FGA), as described by Blaveri et al (2005).
The severity of AD-related neuropathological changes was defined using the Braak stages for neurofibrillary tangles (NFTs) and the Thal phases for amyloid plaque deposition [ 23, 24] in the medial temporal lobe.
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When changes in the chromatin states are inherited trough mitotic or meiotic cell division, the mechanisms responsible for these changes are defined as epigenetic.
The landscape patterns changes were defined as transition areas in which the change of function has been performed in the study time period.
SAFES methodology was applied to cod process where three matrix of changes were defined corresponding to the three main stages of the process.
Changes are defined as differences between future values and seasonal C grazing during the reference period (1981 2010) respectively.
Finally, "flip" exon changes were defined as any case where exons in the same event were positioned on opposite strands.
Intron gain/loss changes were defined as single exons that overlapped 2 or more exons in the other genome.
Exon gain/loss changes were defined as single exons that overlapped no exons in the other genome.
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