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The FAL (Fractional Allelic Loss) and FRL Fractional Regional Losss) indices were calculated as an expression of the amount of allele loss, and an increasing severity of histological changes was characterised by a significant rise of both index means (P<0.001; Table 1).
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Such changes were characterised using scanning electron microscopy (SEM).
By using methods such as sedimentological evidence, historical sources, planimetric resurvey, repeated longitudinal and cross-profiling and hydraulic data, the geomorphological and hydraulic responses to channel changes are characterised and their consequences assessed.
MRI changes are characterised by high T2-FLAIR lesions predominantly affecting the supratentorial subcortical white matter, which tend to be asymmetric and multifocal in nature.
Likewise to our findings, these changes are characterised by the formation of actin stress fibres, which in turn align towards the longitudinal cell axis and mainly appear near the nucleus [8, 31].
These changes are characterised both at the overall fracture scale, as regards its mechanical and hydraulic behaviour, and at microscopic scale through mapping the morphology and mineralogy of the fracture walls and also the voids.
These changes are characterised by a decrease in the number of barriers that restrict the movement of water, thus causing ADC to increase in brain areas where neurodegeneration occurs.
These changes were characterised by the lack of Delta ligand expression in Lkb1-deficient secretory cells and a significant increase in the levels of the downstream Notch signalling effector Hes5 but not Hes1.
The short-term changes were characterised by a total depletion of IgD+CD38+ B cells in BM.
The changes were characterised by the tissue containing shrunken adipocytes and this was paralleled by an increase in interstitial space.
These changes were characterised by an early loss of microvilli and by major cell conformational changes including blebs or buds on the cell surface membrane.
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