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Conventional rheological and chemical tests provide a global view of asphalt property and composition changes upon aging, but offer little details on the changes at the microscopic level.
The color coded presentation of profiles revealed that many gene expression changes upon aging are also differentially expressed upon serial passaging in vitro (figure 2).
Decrease of the 5-methylcytosine content upon aging has been demonstrated almost 40 years ago in the brain, heart and spleen of rats [6] and there is even evidence, that the global methylation level changes upon aging in plants [41].
Changes upon aging of MSC and HPC are related to those of replicative senescence of MSC in vitro and this indicates that our stem and progenitor cells undergo a similar process also in vivo.
Therefore, we excluded CpGs with clear DNAm changes upon aging.
Table S4 Gene ontology analysis of methylation changes upon aging.
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In contrast, transcripts being not changed upon aging showed no transcript shortening, independent of the poly(A) length in fresh eggs (Fig. 6B).
In our Tg-AD mouse, the pro-AD environment promotes and accelerates changes that, upon aging, are otherwise occurring in WT animals.
This vital function is accomplished over a long period of time with almost the same performance, although heart properties, as its elasticity, change drastically upon aging or as a result of diseases like myocardial infarction.
We employed it as a mapping reference for RNA-seq experiments and identified genes which transcript levels were significantly changed upon ageing.
Here we investigate compositional, structural, and magnetic changes that occur upon aging of "2-line" ferrihydrite in the presence of adsorbed citrate at elevated temperature.
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