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Cancer progression, invasion, and metastasis require and/or bring about changes to tumor microenvironments that involve protein degradation by cancer degradome proteases [6].
Finally, we determined that differences in Vegf, Pdgf, and GM-CSF gene expression induced by our combination therapy resulted in changes to tumor vascularization.
All these modifications may alter Warburg and reverse Warburg effects, but it is important to remember that the real contribution of these metabolic changes to tumor cell survival and clinical prognosis remains unclear.
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Once the tumor phenotype is established, FASN elicits several changes to the tumor cell and becomes intertwined with its survival.
While fibroblasts can have tumor suppressing activity the phenotype of the fibroblast changes to a tumor promoting state as carcinogenesis progresses [2].
For the transcriptional changes to impact tumor cell growth, it is crucial that they translate into protein changes.
These control CTs are performed on a regular basis during the course of precision radiotherapy for verification of patient positioning and to monitor any anatomical changes to the tumor and to normal tissue.
Furthermore it will provide a possible new foundation of how specific genes changing the epigenome can influence more drastic changes leading to tumor evolution.
However, brain metabolism regularly changes due to tumor infiltration, for instance [ 26, 27].
All these processes are potentially affected by the metabolic changes linked to tumor growth.
Thus, it is reasonable to speculate that these chromatin structure changes contribute to tumor development and proliferation.
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