Any major change to the significance of predictor would suggest that a factor had not been adequately controlled for and could bias the results.
Standard errors were clustered at the village level for all analyses because villages served as the primary units in the sample selection; we also repeated all analyses while clustering the standard errors at the district level, without a qualitative change to the significance level.
These structural alterations were restricted to the jejunum as changes to the ileum did not reach significance (P>0.05).
Changes in the comparable housekeeping gene can lead to changes in the significance and expression of the target gene using RT-PCR approaches to quantifying gene expression [96], [97].
The value of 1.96 might change according to the significance level in each study.
The case is somewhat more complicated at the conceptual level, since it does not seem open to any individual language-user to change the significance of his/her concepts at will.
Second, identifying significant changes when testing thousands of edges at once will either require a large cohort or strong network changes, as the significance threshold needs to account for multiple testing.
As this was an exploratory study, instead of a confirmatory study with an increasing number of family-wise null hypotheses to test, we have refrained from a Bonferroni-like correction to change the significance level α = 0.05 [ 24].
An amino acid substitution occurred near the interaction site with a nuclear-encoded subunit of the cytochrome c oxidase complex and was predicted to lead to a functional change, although the significance of this remains unclear.
Sensitivity analyses that additionally adjusted these models for preoperative pain and functional limitation led to no change in the significance, and minimal change in the strength of association of these variables (gender, age, depression) at 2 and 5 years.
Overall, the sensitivity analyses did not lead to any change in the significance or direction of effect for the association between the combined consumption of fruit and vegetable and risk of all cause mortality (see table B, appendix 1).
