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Minor changes to the sequence included the Rover SD1 changing into a Ford Sierra in 1993, and again being replaced by a Vauxhall Vectra in 1997.
Evolutionary changes to the sequence of the genome will direct reorganization of GRN architectures, which in turn will lead to the alteration of developmental programs.
Recent findings have confirmed important examples of heritable changes that cannot be explained by changes to the sequence of nucleotides in the DNA.
"Raw sequence data will be freely available," he says, "but significant changes to the sequence data will be protected".
There are two types of modification to a public sequence record: changes to the sequence, or changes to the annotation or description of that sequence.
Interestingly, there are instances in beetles of frame shift mutations causing the mTERF site to become part of the coding region despite no changes to the sequence of the recognition site [ 70].
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Bacteria can evolve by changes to the sequences of existing genes and regulatory regions and by changes to their gene content.
Ralser et al. (19) reported that the W303-derivative K6001, a key model organism for research into aging, shares >85% of its genome with S288C, differing at >8000 nucleotide positions, causing changes to the sequences of 799 proteins.
For example, in the case of Borrelia burgderfori the first ORF is located in the leading strand, so it was included without any change to the sequence.
Each amino acid codon was changed to the sequence GBC (where B was a 1 1 1 ratio of the bases C, G and T) that introduced the codons GCC (Ala), GGC (Gly) or GTC (Val).
However, analyses of the iwhite sequence demonstrated no changes to the donor sequence, which would be predicted at some frequency according to the DSBR model.
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