Sentence examples for changes to the conformation from inspiring English sources
At each gate there is a mechanochemical transition that results in changes to the conformation of the neck linkers, the strength of the binding between the heads and the microtubule, and the kinetics of ATP hydrolysis.
Thus, the p.N306I polymorphism was sufficient to modulate the effect of EVER2 on TNF- α-induced apoptosis and NF- κB activation significantly, probably through slight changes to the conformation of EVER2.
Inspection of the structure also indicated significant changes to the conformations of D270 and P329 in the CH2 domain that could negatively impact C1q binding.
In this respect, the structure of sumoylated F1 + F2 resembles those of other covalent SUMO conjugates, which mostly adhere to a "beads-on-a-string" model where SUMO is flexibly tethered to its substrate without extensive non-covalent contacts or changes to the conformations of the target protein or SUMO itself [46 50].
The different inhibitions of enzyme activity could be explained by the lysozyme conformational changes, where GO induced more changes to the protein conformation according to UV vis absorbance, far-UV circular dichroism spectra, intrinsic fluorescence quenching, and infrared spectra.
It was expected that with an increased milking interval between the two subsequent milkings the changes to the udder conformation could positively affect the attachment success at the second attempt.
Thus, DCC binding induces no significant changes to the overall conformation of the cassette.
At pH 5.5, the CD spectrum resembles a predominantly i-motif DNA population, after addition of 1 mM (100 eq). of Cu2+, the CD spectrum changes to the alternative conformation.
Assuming the only reason for the enhancement in activity stems from the binding of eIF4G and the accompanying change to the closed conformation, no additional enhancement would be expected once eIf4A is in the closed conformation.
Only those with carboxylate side groups able to couple change to the "modulation conformation" with receptor movement are active.
Significantly, it can be seen that an interaction of S101R with PtdIns 3,4,5) P3 did not elicit a change to the protein conformation fingerprint (see the D/ f plot in Figure 7F).
