Sentence examples for changes to mediate from inspiring English sources

Our structural and biochemical data suggest that Pch2/TRIP13 engages its substrates within the hexamer pore, and undergoes coordinated ATP hydrolysis-coupled conformational changes to mediate substrate unfolding.

Taken together, the data indicate that both the overall activity of Nrf2 pathway and expression level of many Nrf2-regulated antioxidant and detoxifying enzymes are decreased in CRI-G1-RS cells; these genetic changes are likely to mediate (or at least contribute to) increased vulnerability to mitochondrial and oxidative stress seen in these cells.

It would be of interest to readers to show alignment of mouse, intervening species, and humans to narrow in on the changes most likely to mediate these properties.

These results suggest that GluR2-lacking AMPARs play a functional and previously unidentified role in learning; they appear to mediate changes in synaptic strength that occur after plasticity has been established by NMDARs.

Although it was unclear if genistein was able to mediate changes in minor monosialogangliosides, the data was more clear cut for improvements in synaptic organisation as shown by VAMP2 staining [16].

Therefore, sha is well positioned to mediate changes in trichome patterning through altered miR-92a activity.

The metabolite effectors are generally able to mediate changes between alternative secondary structures by binding to a metabolite sensing domain of the RNA which prevents translation.

Since transcript-tion and translation are coupled in mitochondria [ 24- 26], these changes probably work together to mediate the increase in OXPHOS complex abundance in tor1 Δ strains.

The fact that Nrp2 (a known receptor for VEGF-C) loss phenocopies VEGF-C loss strongly suggests that VEGF-C acts through Nrp2 to mediate changes in Sod3 levels and the response to oxidative stress.

Ultimately, all these pathways would be expected to mediate changes in an individual's biological/physiological risk factor profile, which is depicted by the farthest left pathway in Figure 1.

Although these stromal changes provide a means through which differences between MGUS and MM can be defined, the impact of these changes and their ability to mediate the transition of MGUS to MM is still unknown and warrants further investigation.