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Changes to genes that control metabolism might trigger or exacerbate conditions such as diabetes or obesity, while disruption to other genes, such as those that govern the body's inflammatory response, might have an impact on heart disease.
Gene-editing tools are known to sometimes make changes to genes other than their intended targets, raising flags about how the changes might affect an animal's health or the composition of milk or meat.
By comparison, nonneutral or what are sometimes called coding changes are changes to genes that lead to measurable changes to organisms.
The genes of mice and human beings have been conserved by evolution, partly because changes to genes are lethal.
Changes to genes are called mutations.
Thus, plant immune systems and pathogen effector systems mirror each other in an additional way, by relying on gene clusters and associated sequence exchange mechanisms to provide rapid and novel changes to genes that control immunity and virulence.
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Long-term spaceflight causes more changes to gene expression than shorter trips, according to research by Weill Cornell Medicine and NASA investigators as part of NASA's Twins Study involving Mark and Scott Kelly.
As the amino-acid sequence is not changed, the mechanism presumably involves changes to gene expression at the level of transcription or translation, or perhaps even changes to protein secondary structure resulting from altered translation rates4,6,7.
Evidence suggests that although convergent evolution is common, parallel evolution can underlie both changes to gene expression and amino acid sequence.
Epigenetic regulation of gene expression occurs due to alterations in chromatin proteins that do not change DNA sequence, but alter the chromatin architecture and the accessibility of genes, resulting in changes to gene expression that are preserved during cell division.
Still, the variables that elicit spikes in an individual — genetics; the population of microbes that live in our bodies; and epigenetics, or changes to gene expression — are critical to understanding glucose dysregulation and the foods that cause glucose spikes.
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