Sentence examples for changes to formulation from inspiring English sources

Expanded IP chapter provisions are also concerning, particularly with the potential for 'evergreening' of pharmaceutical patents, or the extension of patents on medicines for slight changes to formulation without the provision of superior benefit [ 11, 12].

Because changes to the formulation often lead to subtle differences, there is a critical need to define techniques to test and insure the quality of these products.

The FDA Food and Drug Administrationn) recently has instituted changes to UFH formulation and it is not known if this has influenced its susceptibility to neutralization by protamine.

This analysis tool allows the prediction of the effects of changes to model formulation, parameter values and external forcing on the full model.

The methodology was able to discriminate between capsules produced using different primary materials i.e. gelatin versus hypromellose, as well as more minor changes to capsule formulation i.e. different material grades and excipients.

That is, the companies that make them simple make small changes to the formulation or delivery system for the drugs every time the patent is about to run out, and then get a new patent to cover the "innovation," thereby giving the "innovator" another several years of exclusivity.

This change does not reflect a change to the formulation of GP MDI, only in the expression of the strength/dose.

This suggests two changes to the standard formulation in economics, where agents are assumed to derive income from individual effort or from luck (which is beyond anyone's control).

Numerous authors started to propose their improvements and changes to the original formulation, including the geometric active contours models [2] (applied to magnetic resonance images of brain) or active contours for segmentation objects without strictly defined edges [3] (tested only on artificial images and pictures) among the most noteworthy ones.

However, slower (generally uncontrolled) rates of freezing and thawing of drug substance in conventional large storage containers (>2L) can lead to greater cryoconcentration (exclusion of solute molecules) resulting in zones of higher protein and excipient concentrations and changes to the desired formulation pH and excipient concentration.

However, future changes to the vaccine formulations and/or schedule can be considered with the current model and it can also be adapted to look at other countries programs.