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Thus valid formulations of bio-systems usually have stable equilibrium, attracting neighborhood trajectories and allowing slight changes to be tolerated without disturbing normality [ 5, 25, 26].
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The SIFT and PolyPhen-2 protein function algorithms predicts this change to be tolerated and benign, whereas the MutationTaster program indicates that this c.13366C > T variant is deleterious.
However, such changes are unlikely to be tolerated by existing elites (Calgaro 2010).
However, when the C. pneumoniae AaxB sequence was submitted to the SIFT web server with a list of 22 observed replacements in the C. trachomatis sequence, all of the changes were predicted to be "tolerated".
As might be expected of a leucine to isoleucine mutation, like that found in the R57 Art5protein prothis, this change is expected to be tolerated by Art5p (Table 1).
The codon is conserved among species, although according to in silico analyses with Polyphen2 (http://genetics.bwh.harvard.edu/pph2/) and SIFT (http://sift.bii.a-star.edu.sg/), this change is predicted to be tolerated.
This transversion resulted in an amino acid change which is predicted to be tolerated by SIFT and MutationTaster, and only probably damaging by Polyphen-2.
I am to be "tolerated"?
Never to be tolerated!
To "tolerate" and to be "tolerated" involves an unequal relationship.
However, only a relatively low number of changes can be tolerated compared to DIAS.
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