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Because it is well established that EMS mutagenesis induces G/C to A/T transitions, the most conservative estimation of mutation density would only consider such base changes to be induced mutations.
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Instead, it may provide a stable chromatin environment that allows transcriptional change to be induced by other factors, possibly acetylated non-histone proteins.
Some of these changes seem to be induced by electrical activity as well.
These pathological changes were considered to be induced by chemotherapy, and the pathological grade was determined to be grade 2a (Fig. 7).
These changes were shown to be induced within the first week after acoustic trauma and to gradually be increased in magnitude during the following days and months [ 22].
These changes are thought to be induced by cachexia mediators such as the inflammatory cytokine TNF α and tumour-derived lipid-mobilising factors (Tisdale, 2002).
Unlike the late effects of anticancer therapy on tumor size, molecular and metabolic changes are well recognized to be induced much earlier, before morphological changes occur [12].
Furthermore, replicative senescence has been shown to be induced by changes in the protected status of the telomeres rather than the loss of TL.
We conclude that the parasitoids, and not the hosts, benefited from the behavioural changes of the host that appear to be induced by the parasitoids.
Such increase is proposed to be induced by changes in the environment [ 16].
From this pilot-scale experiment with 10 target genes, we were able to identify 57 nucleotide changes, most of which were inferred to be induced by mutagen treatment.
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