Exchanging the normalization methods between data sets changed the background intensities but changed the variability of technical replicates only to a small extend (data not shown).
While the components are statistically significant and reflect major changes in the variability of the data, the connection to the physical properties PCA highlights is always non-trivial.
Since the shape of the f-I curve depends on both the mean and variance of theinput current [25, 26], it might appear invalid to discuss changes in the variability of input currentdue to dynamic synapses in the context of a fixed f-I curve.
Moreover, the precision of psychometric tests used in this population may not be adequate to detect subtle changes given the variability of the tests themselves.
The upper panels in Figure 3 A and D illustrate the corresponding age-related trends of changes in the variability of brain signals associated with the information processed locally.
In particular, since the mean electrical phenotype reaches a steady-state by P14 P15, we tried to determine whether this stabilization was also associated with changes in the variability of the phenotype.
This enabled us to test whether effects of age on VWM precision are due to a change in the variability of stored features, a change in the number of items which completely fail to be stored, or some other factor, for example a change in the frequency of misbinding (Cowan et al., 2006a).
This method assumes no change in the variability of SST between these two time periods, which was confirmed by examining the 30-year running s.d. of SST from HadISST (Supplementary Fig. 9).
For this reason, in [2], the authors assumed that the growth deceleration factor b did not change while the variability of environmental conditions induced fluctuations in the intrinsic growth rate a.
