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Rab39B co-localizes with Htt and changes the localization of Htt, protecting it from degradation.
Finally, similar to Mps1 [21], we show that during mitosis hypoxia changes the localization of Polo, suggesting a role for this protein in mediating the hypoxic response.
The Nucleo-cytoplasmic Transport, which requires three factors, eIF Set, Dhh1p, and Pat1p, changes the Localization of the mRNA from nucleus to P body.
The two other transport processes are the inverse of each other: P Body-Ribosome Transport changes the Localization of the mRNA from P body to ribosome and induces translation initiation, while Ribosome-P body Transport does the opposite, repressing translation.
Therefore, neither reduction of Hyou1 gene dosage, nor loss of Dnajc3, changes the localization of the inclusions, but rather changes the timing of protein aggregation.
The LHCI role in PSI photoprotection is thus dual: its presence not only increases the overall resistance to high light, but also changes the localization of the radiation damage far from the reaction center, acting like a safety valve.
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Overexpression of UFM1 did not change the localization of UFM1, still cytoplasmic and ER (Figure 4F).
As a result, the WT FBXO7 N-terminal 40 amino acid peptide, but not the T22M-mutant, was able to change the localization of profilin from cytoplasm to nucleus (Figure 6).
This mutation changed the localization of FMRP from cytoplasmic to nuclear.
Remarkably, exogenous hypoxia (0.2% O2) in PC-3 cells induced intracellular hypoxia and changed the localization of the prenylated proteins.
Indeed, KLK did not change the localization of CD43-YFP when the cells were pretreated by neuraminidase (Fig. 6).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com