Sentence examples for changes the chromatin from inspiring English sources
These results lead us to hypothesize that transcription across DMRs changes the chromatin state to become permissive for DNMTs.
HMGB1 was initially identified as a widely existing DNA binding protein, which changes the chromatin or DNA configuration and regulates the transcription complex formation [ 6].
Recently, the lamin Dm0 protein has been shown to colocalize with conserved microsynteny in Drosophila (Ranz et al. 2011), whereas Chromator changes the chromatin folding state (Rath et al. 2006).
It may be presumed that any process that changes the chromatin conformation with a concomitant release of histone N termini could provide a structural basis for binding of SET domains to nucleosomes.
For instance, KCl-mediated depolarization of neurons changes the chromatin accessibility of several differentiation-associated genes, such as NCAM and TH, and can subsequently alter the differentiation path of neurons [ 58, 60].
Our comprehensive characterization of reprogramming-associated molecular changes broadens our understanding of this process and sheds light on how TFs access and change the chromatin during cell-fate transitions.
The ∼150 kb Snord116 deletion could potentially change the chromatin conformation of the flanking region or remove regulatory elements and, thus, affect the expression of neighboring genes.
To investigate whether restoration of CTCF binding could change the chromatin structure separated by the presumable insulator sequence in H1299 lung cancer cells, we treated H1299 cells with both the DNA demethylating agent AZA and the HDAC inhibitor TSA.
It was interesting that AZA and TSA treatment of H1299 cancer cell changed the chromatin structure in downstream sequences between BLU and RASSF1A genes, but not upstream of the CTCF binding sites (Fig. 6A and the upper panel of 6B).
Our results that AZA and TSA treated H1299 cancer cell changed the chromatin structure nearby the RASSF1A promoter, but not upstream of the CTCF binding sites between RASSF1A and BLU loci supported their mechanisms [41] [43].
