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The cholesterol reduction changes the cell membrane morphology and the plasma membrane of the cells become less rigid.
The regulation on cell wall synthesis changes the cell rigidity: E. coli with thickened cell walls accumulated only 25% PHB while cell wall weakened E. coli produced 93% PHB.
When DNA uptake changes the cell's genotype, the cell is said to be transformed.
Meanwhile integrin binding to the ECM changes the cell shape and the composition of the cytoskeleton beneath [8].
Although previous work has used optical trapping to study intercellular immune synapses [34], [42], these studies did not observe the dynamic membrane changes the cell undergoes as it binds to another cell or bead.
Since Pofut1-deficient hair follicles turned into epithelial cysts during the second hair cycle, immunohistochemical analyses were performed to determine whether abrogation of Notch signaling changes the cell fate choice of bulge stem cells.
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New neurons may be specifically involved in formation of the synaptic network serving as the structural basis for long-term synaptic changes (the cell-autonomous hypothesis).
For better understanding of the cell immobilization and morphology changes, the cell-hydrogel interaction should be further examined.
To screen for smaller genetic changes, the cells were tested on Affymetrix 50K SNP chips.
These genes can change the cell's behavior by turning other genes on and off.
"The minute you change the cell line, you're going to make a different product," said Robert L. Garnick, senior vice president for regulatory affairs, quality and compliance at Genentech.
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