Sentence examples similar to changes that impaired from inspiring English sources

Last but not least, there is also increasing evidence that the resident cells of chronic wounds may undergo phenotypic changes that impair their capacity for proliferation and movement.

Overall, the data verifies that proteostasis-imbalance is an early age-related change that impairs the ability to counteract endotoxin (Pa-LPS) or sepsis (CLP) mediated inflammatory insults.

However, radiation therapy may cause hypoxic, hypovascular, and hypocellular changes that impair normal collagen synthesis and cell production and lead to tissue breakdown and the formation of chronic non-healing wounds [1].

These findings not only reveal epigenetic features associated with the normal function of adult stem cells but also provide a framework for dissecting the epigenetic changes that impair stem cell function with age.

A summary of the HDAC8 catalytic mechanism is shown in Figure 2. Recently, we reported X-ray crystal structures of five missense mutants of HDAC8 identified in children diagnosed with CdLS, showing how individual amino acid substitutions 8 25 Å away from the active site can trigger local conformational changes that impair catalytic activity and thermostability.

This work highlights the successful development of an experimental methodology to study time dependent changes in lipid biophysics in simple SC model membranes and suggests this approach will prove useful for understanding some of the biophysical changes that underlie impaired physiological barrier function in diseased skin.

In clinical practice they may be considered mainly for evaluating the presence and extent of crystal deposition, and structural changes that may impair function or functional outcomes, and also to monitor the response to urate-lowering therapy.

Previous studies on the innate response of macrophages during intracellular bacterial infection suggested that SLC11A1-mediated deprivation of divalent cations might change the phagosomal microenvironment that impairs the pathogenesis of intracellular pathogens [20].

Metabolic changes that result from impaired intestinal mucosal perfusion have been shown by tonometry measurements that demonstrate worsening acidosis in mucosal cells with increasing IAH [ 21].

Nonsteroidal anti-inflammatory drugs are recommended for the relief of pain associated with hand osteoarthritis (OA) but do not alter the underlying structural changes that contribute to impaired physical function.

That impairs problem-solving".