Sentence examples for changes that impair from inspiring English sources

However, radiation therapy may cause hypoxic, hypovascular, and hypocellular changes that impair normal collagen synthesis and cell production and lead to tissue breakdown and the formation of chronic non-healing wounds [1].

Last but not least, there is also increasing evidence that the resident cells of chronic wounds may undergo phenotypic changes that impair their capacity for proliferation and movement.

These findings not only reveal epigenetic features associated with the normal function of adult stem cells but also provide a framework for dissecting the epigenetic changes that impair stem cell function with age.

A summary of the HDAC8 catalytic mechanism is shown in Figure 2. Recently, we reported X-ray crystal structures of five missense mutants of HDAC8 identified in children diagnosed with CdLS, showing how individual amino acid substitutions 8 25 Å away from the active site can trigger local conformational changes that impair catalytic activity and thermostability.

Cornell neuroscientist Adam Anderson, associate professor of human development, said that his research suggests that positive emotions are associated with increased cognitive flexibility and creative problem solving, and this may be due to neural changes that impair selective attention.

The research helped establish that--unlike Alzheimer's disease, in which whole neurons degenerate--normal aging does not damage the neural circuitry that underlies memory; instead, it seems to bring about subtle molecular changes that impair communication among neurons.

Overall, the data verifies that proteostasis-imbalance is an early age-related change that impairs the ability to counteract endotoxin (Pa-LPS) or sepsis (CLP) mediated inflammatory insults.

In clinical practice they may be considered mainly for evaluating the presence and extent of crystal deposition, and structural changes that may impair function or functional outcomes, and also to monitor the response to urate-lowering therapy.

This work highlights the successful development of an experimental methodology to study time dependent changes in lipid biophysics in simple SC model membranes and suggests this approach will prove useful for understanding some of the biophysical changes that underlie impaired physiological barrier function in diseased skin.

Metabolic changes that result from impaired intestinal mucosal perfusion have been shown by tonometry measurements that demonstrate worsening acidosis in mucosal cells with increasing IAH [ 21].

Nonsteroidal anti-inflammatory drugs are recommended for the relief of pain associated with hand osteoarthritis (OA) but do not alter the underlying structural changes that contribute to impaired physical function.