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Carcinogenesis is generally regarded as a multi-step process requiring an undefined number of mutations and/or epigenetic changes that confer specific growth advantages and/or permit bypass of tumor-suppressive mechanisms [29].
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Engineered protein tags that confer specific binding to standardized affinity resins have revolutionized recombinant protein purification.
HLA heterozygosity undoubtedly contributes to general resistance to pathogens, but the specific alleles that confer specific resistance provide more protection under these conditions.
There are more than 100 PP1 regulatory subunits that confer specific functions to cellular PP1 catalytic subunits.
Studying these regions is a way to trace evolutionary changes that confer some of our uniquely human traits.
Their application led to the successful design of artificial 3′ UTRs that conferred specific mRNA dynamics.
To help define the TAS2R16 ligand structural features that confer specificity, we first tested the agonist activity of a panel of twelve readily available salicin analogs representing specific structural changes in the β-glucoside core constituents (R groups, glycosidic linkage, and monosaccharide units).
In such cases, there are collective arrangements that confer relatively specific meanings on relatively specific objects.
In addition, we identify mutations that confer species-specific resistance, or antifolate-specific resistance.
Connective tissues are complex composite materials of cellular and extracellular matrix components that together confer specific biological and structural properties.
Protein domains are independently folding structural units that often confer specific functions.
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