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Exact(14)
Preconditioning is the phenomenon whereby prior exposure to a stimulus, often one normally held to be injurious, triggers phenotypic changes that confer resistance to subsequent insults.
Investigations of changes that confer mammalian transmissibility to avian H9N2 (11), H7 (6), and H5N1 viruses (10, 15) have begun to provide insights.
Cancer is thought to arise from a series of genetic and epigenetic changes that confer oncogenic properties on a cell and its descendents (reviewed in [1]).
Carcinogenesis is generally regarded as a multi-step process requiring an undefined number of mutations and/or epigenetic changes that confer specific growth advantages and/or permit bypass of tumor-suppressive mechanisms [29].
Accordingly, genomic changes that confer selective advantages enabling their survival and proliferation have been identified in diverse species.
The repertoire of defense proteins available to an organism is being constantly reshaped through genomic changes that confer resistance to pathogens.
Similar(46)
It was not paper money he was handing out, of course, it was something much more valuable -- rule changes that conferred a greater ability to take on reckless risk, damage consumers, and impose higher future costs on the taxpayer.
In conjunction with additional changes that diminished the receptor's sensitivity to aldosterone and increased its sensitivity to cortisol, these permissive changes allowed an additional and subsequent set of function-switching amino acid changes that conferred a fully GR-like phenotype that is sensitive only to cortisol.
It was shown that mitaplatin elicits cytotoxic effects upon cisplatin-resistant head and neck tumour cells [ 31] by a dual killing mode: cisplatin interacts with the DNA while the action of the dichloroacetate is focused on the mitochondria by reversing the mitochondrial changes that confers cancer cells resistance to apoptosis.
Cross-resistance: The propensity of a genetic change that confers resistance to one drug also to affect resistance to a different drug (by either increasing or decreasing resistance).
However, the simple definition of the high level phenotype in this instance as a 'drought tolerance trait' will probably prove too limiting for a robust risk assessment, since the nature of the change that confers drought tolerance may lead to differing risk perspectives.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com