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Two common variants [minor allele frequency (MAF) ≥5%] were observed in Sb06g033060 (at nucleotide S6_61108872 in Sbi1.4) and Sb10g018720 (at nucleotide S10_40095764), both of which contain nucleotide changes that can alter the amino acid sequence relative to the sorghum reference genome (Paterson et al. 2009).
Inhibiting lymphocyte DNA methylation during mitosis alters gene expression, resulting in immunogenic changes that can alter the response to self-antigens, including overexpression of the adhesion molecule LFA-1 (CD11a/CD18), the cytotoxic molecule perforin, and B-cell costimulatory molecules CD70 and CD40L (Ballestar et al. 2006).
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It may prevent consumption of wetland plants needed to sustain the bird within a particular year, but exclusion of grazing over decades may also lead to vegetation change that can alter the habitat due to invasion of shrubs, vines, and other woody species into the wetland, creating a state three ecosystem.
For chronic models there are the problems of overlying pathophysiological change that can alter the initiating insult.
The disadvantage of this method is difficulty in detection of multistrain infections and minute changes in sequence that can alter virulence.
85, 86 Challenges with these studies include the uneven and seasonal changes in income that can alter impact 85, 86 and complexities of estimating the value of bartered goods and services.
A caution should be exercised regarding genetic changes in malignant tissue that can alter the repeating segments used in the forensic DNA fingerprinting, thus leading to potentially false non-matches.
In addition to the oncogenic and epigenetic changes within the tumor that can alter mitochondrial function, tumor mutations have been found in mitochondrial DNA, and in nuclearly encoded mitochondrial enzymes.
The latter include base compositional heterogeneity (Foster 2004; Jermiin et al. 2004) and lineage-specific changes in evolutionary constraint that can alter the proportion of variable sites in homologs (Lockhart and Steel 2005).
MM cells directly and indirectly impose changes in the BM milieu that can alter remodeling of the BM extracellular matrix and regulation of immune compartment [ 29].
This would result in changes in the expression of genes that can alter actomyosin contractility.
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