While it is generally assumed that changes in steady-state mRNA levels stem from changes in the rate of transcription, varying the rate of degradation also changes steady-state levels; this phenomenon has been observed at both mRNA and protein levels in the cold acclimation of fish (Sidell, 1977; Bremer and Moyes, 2014).
However, linear demand, quadratic demand and exponential demand rates require uniform change, steady increase or decrease and rapid changes in demand rate, respectively.
The first three global PPCs (i.e., dynamic change, steady state, and discontinuous change constraints) are exclusive for the same reason.
Simulation of this condition predicts modestly faster core PCP polarization compared to random distal MTs, but not to change steady state core PCP polarization.
For disturbances which change steady state expression levels by more than about 5%, our simulator showed a behavior which cannot directly be captured by a linearized approach.
Whether the increase in CRP levels only reflects a changed steady-state metabolism is unknown.
Cu2+ addition to the bath significantly changed steady-state RF impedance |ΔZRF|s in ShB-IR expressing oocytes relative to controls.
Long-term ISO stimulation also changed steady-state activation (P < 0.01), inactivation (P < 0.01), and recovery (P < 0.05) characteristics of LTCC in SUS group.
It has already been shown that mutations within a deubiquitinase enzyme, UBP6, can dramatically change steady-state ubiquitin levels within a cell [ 39], which is known to affect tolerance to a variety of stressors [ 40- 42] and yeast prion toxicity [ 42].
This research also needs to look at changes in steady state conditions (i.e. rate of change) for temperature and dew point.
Different scenarios are simulated to observe the impact of possible changes and steady state of the system after the iteration process in HFCM.
