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If the CUP in fact is the primary cancer, the tumor may have undergone massive phenotypical changes, seeming to be metastatic tissue, whereby it is not diagnosed as a primary tumor [ 5].
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The changes seemed to work.
Later changes seemed to prove him right.
But the changes seem mostly cosmetic.
In some ways, these changes seem cosmetic.
The changes seem to be paying off.
Some changes seem more benign than others.
In isolation each of these changes seems perfectly sensible.
"These changes seem small, but they are essential.
For the most part, the plot changes seem wise.
Furthermore, the changes seemed to last for some time.
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