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The evolutionary quality of local sequence changes resides in the occasional improvement of a biological function.
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Interestingly, many changes reside in cis-regulatory elements (CREs) that control the expression of an unmodified coding sequence.
These data confirm that the two sequence changes reside on different chromosomes (in trans), and therefore the asymptomatic subjects are compound heterozygotes for these two AIP changes.
Three amino acid changes are confined within known antibody-binding sites, i.e., the S189N change within antibody-binding site B (4, 5) and the V226I and S227P changes residing in antibody-binding site D (4, 5).
So that's the place where potential change resides.
From many, many perspectives, the relationship between the mother and child and between the father and child is where change resides.
The institutional memory of how the world has changed resides in the Pentagon.
Additionally, the change resides in the region recently identified as the second 'Nuclear Export Signal (NES)' i.e., amino acids 168-179 [ 14].
However, the mutational change resides within a transmembrane helix region that faces towards the mitochondrial intermembrane space (Additional file 6: Figure S3) and is predicted to have a neutral effect (Table 2).
This may occur if a patient changes residence and no longer resides in the region served by the QEII PCP, their health had improved such that they are no longer considered palliative or they had a change in their personal caregiver.
Even the elections of governors and state legislators are likely to be more consequential than who wins the presidency because so many of the powers to curb climate change reside at the state level.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com