Exact(5)
Whereas doctors in the clinic focus on phenomena such as symptoms, drug effects, and treatment outcomes, basic scientists often concentrate on activity at the molecular and cellular levels such as genetic alterations, gene expression changes, or protein profiles.
Of course, multiple site incorporations of tfmF and 19F-NMR will be required to reflect the uniform changes of the sample conditions, e.g. acidification, viscosity changes or protein degradation.
The relationship between genetic aberrations and gene expression changes or protein function aberration is strongly established.
Interestingly, most QTGs identified in animal models have the causal polymorphisms in the protein-coding region [ 14], which provoke protein structure changes or protein deficiency.
For example, mutations of specific nucleotide change (e.g., C->T in melanoma), or mutations causing critical amino acid changes or protein structure alterations, will likely be more informative.
Similar(55)
The database also has search function capabilities such as location, classification, mutation type, literature reference, nucleotide change, or protein change.
In addition, users can search for variants by location, classification, mutation type, literature reference, nucleotide change, or protein change.
Data also suggest that protein stability and degradation are significantly affected by formaldehyde exposure; such changes might arise from direct formaldehyde modification of proteins, redox changes, or altered protein nitrosylation.
On the other hand, if adaptive evolution was the factor underlying this unusual acceleration, then it is to be expected that it would affect the restricted group of genes encoding proteins whose functions have changed, or proteins that help the organism to get adapted to new or changing environments.
Now the question is whether we can use potentially therapeutic interventions to change gene or protein expressions from undesired states to desired states.
If the amount of this protein is changed or the protein is modified such as up-regulation, down-regulation, phosphorylation, dephosphorlyation, glycosylation and methylation, it should affect the metabolism of nucleotides in cells.
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