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Rapid changes on the endpoint will dramatically challenge other cybercorns.
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The secondary efficacy parameter was the baseline-to-endpoint score change on the 19-item Alzheimer's Disease Cooperative Study Activities of Daily Living (ADCS ADL19); additional parameters included the baseline-to-endpoint score changes on the Neuropsychiatric Inventory (NPI) and verbal fluency test.
"Not a lot has changed in the endpoint security landscape over time," says Weingarten. "While now we're seeing much more sophisticated attackers and realizing that they can penetrate networks on the end devices.
Conceptually, remission is more appropriate than change as the endpoint.
Table 2 presents changes on the eight primary and secondary outcome measures from baseline to endpoint, and self-reported ratings of change at endpoint.
This depends on the endpoint and on the chemical.
This protocol was based on the endpoint strategy.
But we had no power to change the endpoint.
Co-primary efficacy parameters were the baseline-to-endpoint score change on the Severe Impairment Battery (SIB) and the endpoint score on the Clinician's Interview-Based Impression of Change Plus Caregiver Input (CIBIC-Plus).
Superiority analyses are designed to show that one treatment is superior to another based on changes in the primary endpoint.
In addition, the insulin glargine group demonstrated significant baseline to endpoint change on the EQ-5D index score and the DSC-R cardiology score.
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