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These findings need attention since mutations in the vaccine strain could result in changes of virulence and efficacy of the vaccine.
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Genetic analysis of mutant virus found that change of virulence may be attributed to the D222G substitution in the HA gene.
For the first time, the acquisition of azole resistance despite azole-echinocandin combination therapy is described in a CGD patient and the resistance demonstrated to be directly associated with significant change of virulence.
These adaptations contribute to the change of virulence of bacteria living in biofilm.
The only difference is that one emphasizes the change of virulence optima during the invasion, the other addresses the range of virulence values that can invade and the nonequilibrium states that may persist after invasion.
To identify a subset of mutations suitable for further attenuation of W1806, we analyzed effects of E138K and K279M changes on virulence, growth properties, and immunogenicity of derivatized W956, from which chimeric W1806 inherited its biological properties and attenuation profile.
We proposed that the seasonal changes of influenza virulence might reflect the frequent antigenic shifts of viruses within an influenza epidemic season.
In part, the experimentally derived fitness costs and benefits are consistent with frequency changes of these virulence factors in the French pathogen population.
The main objective of this study was to determine molecular characteristics of recently isolated Polish strains of MDV and to identify factors responsible for changes of MDV virulence; changes that are commonly associated with mutation of the nucleotide sequence of meq oncogene [ 10].
We then examined the biological and physicochemical consequences of these changes to virulence.
It is not clear at this point if these changes in expression of virulence genes affect the intracellular multiplication of Lp in host cells after incubation in water.
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